Key Concepts
This chapter discussed alterations in the endocrine system. The nursing student should use these key concepts to answer questions as they relate to the care of this client. Remembering the pathophysiology of the disease process, the treatment, and the laboratory values will help you to be able to answer questions in the physiologic integrity portion of the NCLEX exam.
Key Terms
- Acromegaly
- Adrenocortical hyperplasia
- Aldosterone
- Androgens
- Addison’s
- Adrenal cortex
- Adrenalectomy
- Bromocriptine (Parlodel)
- Buffalo hump
- Corticosteroids
- Cortisol
- CT scan
- Cushing’s disease
- Diabetes insipidus
- Dostinex (carbergoline)
- Estrogen
- FSH (follicle-stimulating hormone)
- Gigantism
- Gland
- Gonadotrophins
- Hirsutism
- Hormones
- Human growth hormone
- Hypopituitarism
- Hypothalamus
- Luteinizing hormone
- MRI (magnetic resonance imaging)
- Ovaries
- Parlodel (bromocriptine)
- Parathyroid gland
- Pituitary gland
- Prednisone
- Progesterone
- Prolactin
- Prolactinoma
- Thymus
- Thyroid gland
- Transsphenoidal hyposection
Diagnostics
The exam reviewer should be knowledgeable of the preparation and care of clients receiving exams to diagnose endocrine disorders. While reviewing these diagnostic exams, the exam reviewer should be alert for information that would be an important part of nursing care for these clients. The pertinent labs and exams are as follows:
- Laboratory test to determine hormone levels
- X-rays to detect tumors
- Computer tomography to detect tumors
- Magnetic imaging to detect tumors
Pharmacological Agents Used to Treat Clients with Endocrine Disorders
An integral part of care to clients with endocrine disorders is pharmacological intervention. These medications provide an improvement or cure of the clients’ endocrine problems. The nursing exam reviewer needs to focus on the drugs in Table 4.1. Included in this table are the most common drugs used to treat endocrine disorders. These medications are not inclusive of all the agents used to treat endocrine disorders; therefore, you will want to keep a current pharmacology text handy for reference.
TABLE 4.1 Pharmacological Agents Used in the Treatment of Clients with Endocrine Disorders
Drug |
Action |
Side Effect |
Nursing Care |
Cortisone, hydro-cortisone, prednisone, and fludrocortisone (Florinet) |
For replacement of a lack of cortisole or to suppress the immune response in a client suffering from allergic reaction, those with organ transplantation, or to suppress untoward effects of medications |
Nausea and vomiting weight gain, decreased immunity. |
Instruct the client to take the medication with meals. Instruct the client to report the signs or symptoms of excessive drug therapy: signs of Cushing‘s syndrome. |
Propylthiouracil (PTU, Propyl-Thracil) |
Used to treat hyperthyroidism |
Slow heart rate, fatigue, drowsiness headache, neuritis, nausea, vomiting, diarrhea, and myelosuppression. |
Measured dosage should be spread over 24 hours to prevent hormone release from the thyroid. |
Methimazole (Tapazole) |
Antithyroid medication |
Same as above. |
Monitor vital signs, weigh the client weekly, observe for throat soreness, fever, headache, and skin ulcers. |
Iodine product, strong iodine (Lugol‘s solution) |
Used to decrease the potential for a thyroid storm, which is an abrupt release of thyroid hormone |
Same as above. |
Bitter to taste, give with fruit juice. |
SSKI (saturated solution of potassium iodide) |
Used to treat and prevent thyroid storm |
Same as above plus: metallic taste, stomatitis, salivation, coryza, hyperthyroid adenoma, irregular heart rate, and mental confusion. |
Signs of hypothyroidism might necessitate discontinuation. |
Potassium iodide tablets, solution, and syrup |
Used to treat iodide deficiency that can lead to a goiter |
Same as above. |
Take after meals to increase absorption. |
Lithium carbonate (Lithobid, Carbolith, Lithizine) |
Used to treat hyperthyroidism |
Dizziness, lethargy, drowsiness, fatigue, slurred speech, psychomotor retardation, incontinence, EEG changes, arrhythmias, hypotension, impaired vision, thyroid enlargement, dry mouth, abdominal pain, pruitus, and thinning hair. |
Observe for hypothyroidism. Instruct the client to drink 8–12 glassfuls of fluids per day. Instruct the client to maintain adequate sodium intake to prevent toxicity. |
Propanolol (Inderal, Detensol) |
A beta blocker used to treat hyperthyroidism |
Bradycardia, edema, lethargy, and bone marrow suppression. |
Monitor pulse rate, CBC, and for signs of congestive heart failure. Take with food to decrease GI upset. |
Atenolol (Tenormin) |
Same as above |
Same as above. |
Same as above. |
Levothyroixine (Levo-T, Levothroid, Levoxyl, Levothyroixine Sodium, Synthyroid) |
Used to treat hypothyroidism |
Tachycardia, nausea, vomiting, diarrhea, and insomnia. |
Check pulse rate routinely. |
Bromocriptine (Alphagen, Parlodel) |
Used to treat parkinsonism or for prolactinomas |
Hypotension, nausea, vomiting, blurred vision, dry mouth, urticaria, and fatigue. |
Watch for orthostatic hypotension. Should not be used by pregnant clients. Dizziness, headaches, abnormal vision, constipation, hot flashes, and parathesia. Check serum prolactin levels <20mcg/liter in women or <1 5 mg. |
Sulfonylureas |
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Carbergoline (Dostinex) |
Used to treat prolactinomas; inhibits prolactin secretion |
May cause headaches, depression, nervous- ness, and fatigue. Dysmenorrhea and facial flushing has also occurred. |
Do not use with clients with liver disease. |
Glimepride (Amaryl) |
Used to treat hyperglycemia; works by increasing effects of client‘s own insulin |
Hypoglycemia, watch for renal function. |
Teach the client to watch for hypoglycemia, GI disturbance, allergic skin reactions, and photosensitivity. Take once daily before meals. |
Glyburide (Micronase, Diabeta, glynase) |
Same as above |
Same as above, plus may cause gastrointestinal disturbance. |
Watch for hypoglycemia. Take in divided doses. |
Glipizide (Glucotrol, Glucotrol XL) |
Same as above |
Same as above. |
Watch for hypoglycemia. Take before breakfast. Doses above 15mg should be divided. Glucotrol XL is long-acting, given one time per day. |
Antidiabetic Medications—Meglitinides |
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Repaglinide (Prandin) |
Used to treat hyperglycemia |
May lead to hypoglycemia. |
Watch for hypoglycemia. If NPO, withhold medication. |
Antidiabetic Medications—Biguanides |
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Metformin (Glucophage) |
Used to treat hyperglycemia; works by decreasing carbohydrate breakdown in the GI tract |
Renal impairment, gastrointestinal upsepo, nausea, and vomiting. |
Watch for hypoglycemia. Can cause GI disturbance, B-12 deficiencies, lactic acidosis, malaise, and respiratory dis-tress. Contraindicated in renal disease clients, liver disease, and congestive heart failure. Clients going for radiographic studies should have gluco-phage withheld for 48 hours or until renal function returns. |
Antidiabetic Medications—Thiazolidinedione |
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Rosiglitazone (Avandia) |
Used to treat hyperglycemia; works by decreasing carbohydrate breakdown in the GI tract |
Abdominal pain, nausea, vomiting, anorexia, and hypoglycemia. |
Watch for hypoglycemia. Clients with liver or renal disease should not take this drug. Monitor liver enzymes. It might decrease effects of oral contraceptives. Watch for signs of congestive heart failure. |
Alpha-glucosidase inhibitor—Acarbose (Precose) |
Used to treat hyperglycemia associated with diabetes |
Flatulence, diarrhea, and abdominal discomfort. |
Watch for hypoglycemia. Take with first bite of food. Contraindicated in clients with liver disease, inflammatory bowel disease, or renal disease. |
Invokana (canagliflozin) |
Used to treat hyperglycemia associated with diabetes. Works by decreasing renal reabsorption of glucose and increasing renal excretion of glucose. |
Check renal function |
Watch for hypoglycemia; Hypotension can occur with use. Watch for signs of hyperkalemia. Might cause a rise in cholesterol. |
Insulins |
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Lispro (Humalog) |
Onset five minutes, so have food available; peak 30–60 minutes; duration 2–4 hours; used to treat uncontrolled diabetes |
Hypoglycemia |
Watch for hypoglycemia. |
Regular insulin |
Onset 30–60 minutes; peak 2–4 hours; duration 6–8 hours |
Hypoglycemia |
Watch for hypoglycemia. |
Intermediate-Acting Insulins |
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NPH |
Onset 1–2 hours; peak 6–12 hours; duration 18–24 hours |
Hypoglycemia |
Watch for hypoglycemia. |
Humulin N |
Same as above |
Hypoglycemia |
Watch for hypoglycemia. |
Humulin L |
Same as above |
Hypoglycemia |
Watch for hypoglycemia. |
Long-Acting Insulins |
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Ultra Lente |
Onset 5–8 hours; peak 14–20 hours; duration 30–36 hours |
Hypoglycemia |
Watch for hypoglycemia. |
Lantus |
No peak; duration 24–36 hours |
Hypoglycemia |
Watch for hypoglycemia. Do not mix with other insulins. Usually given at night; however, the FDA has recently approved administration during the day. |
Combination Insulins |
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Humulin 70/30 |
Onset 30 minutes; peak 4–8 hours; durations 22–24 hours |
Hypoglycemia |
Watch for hypoglycemia. |
Humulin 50/50 |
Onset 30 minutes; peak 4–8 hours; durations 22–24 hours |
Hypoglycemia |
Watch for hypoglycemia. |
Exubera |
An inhaled form of insulin recently released and approved by the FDA; delivers insulin directly into the lungs; rapid onset; duration several |
Hypoglycemia |
Watch for hypoglycemia. |